Description
Buy URB-602 Online
Buy URB-602 Online, URB602 ([1,1′-biphenyl]-3-yl-carbamic acid, cyclohexyl ester) is a compound that has been found to inhibit hydrolysis of monoacyl glycerol compounds, such as 2-arachidonoylglycerol (2-AG) and 2-oleoylglycerol (2-OG). It was first described in 2003. A study performed in 2005 found that the compound had specificity for metabolizing 2-AG over anandamide (another cannabinoid ligand) in rat brain presumably by inhibiting the enzyme monoacylglycerol lipase (MAGL), which is the primary metabolic enzyme of 2-AG.
URB602, The data demonstrate that the compounds URB602 and URB754 do not behave as selective and/or potent inhibitors of monoacylglycerol lipase.
Keywords: 2-acylglycerol, anandamide, monoacylglycerol lipase, fatty acid amide hydrolase, URB597, URB602, URB754
IUPAC name: Cyclohexyl [1,1′-biphenyl]-3-ylcarbamate
Other name: [1,1′-Biphenyl]-3-yl-carbamic acid, cyclohexyl ester
CAS number: 565460-15-3
Formula: C19H21NO2
Buy URB-602 Online, URB602 ([1,1′-biphenyl]-3-yl-carbamic acid, cyclohexyl ester) is a compound that has been found to inhibit hydrolysis of monoacyl glycerol compounds, such as 2-arachidonoylglycerol (2-AG) and 2-oleoylglycerol (2-OG). It was first described in 2003. A study performed in 2005 found that the compound had specificity for metabolizing 2-AG over anandamide (another cannabinoid ligand) in rat brain presumably by inhibiting the enzyme monoacylglycerol lipase (MAGL), which is the primary metabolic enzyme of 2-AG.
URB602, The data demonstrate that the compounds URB602 and URB754 do not behave as selective and/or potent inhibitors of monoacylglycerol lipase.
Keywords: 2-acylglycerol, anandamide, monoacylglycerol lipase, fatty acid amide hydrolase, URB597, URB602, URB754
IUPAC name: Cyclohexyl [1,1′-biphenyl]-3-ylcarbamate
Other name: [1,1′-Biphenyl]-3-yl-carbamic acid, cyclohexyl ester
CAS number: 565460-15-3
Formula: C19H21NO2
Buy URB-602 Online, In cytosolic fractions from rat brain, URB602 and URB754 inhibited the hydrolysis of 2-oleoylglycerol with IC50 values of 25 and 48 μM, respectively. Anandamide hydrolysis by brain membranes was not sensitive to URB754, but was inhibited by URB602 (IC50 value 17 μM). Hydrolysis of 2-oleoylglycerol by human recombinant monoacylglycerol lipase was sensitive to URB602, but not URB754.
Buy URB-602 Online, The lack of selectivity of URB602 for 2-oleoylglycerol compared to anandamide hydrolysis was also observed for intact RBL2H3 basophilic leukaemia cells. C6 glioma expressed mRNA for monoacylglycerol lipase, and hydrolyzed 2-oleoylglycerol in a manner sensitive to inhibition by methyl arachidonoyl fluorophosphonate but not URB754 or URB597. MC3T3-E1 mouse osteoblastic cells, which did not express mRNA for monoacylglycerol lipase, hydrolyzed 2-oleoylglycerol in the presence of URB597, but the hydrolysis was less sensitive to methyl arachidonoyl fluorophosphonate than for C6 cells.
Buy URB-602 Online, Purity: 99,9% min
Appearance: white powder
Two compounds, URB602 and URB754, have been reported in the literature to be selective inhibitors of monoacylglycerol lipase, although a recent study has questioned their ability to prevent 2-arachidonoyl hydrolysis by brain homogenates and cerebellar membranes. In the present study, the ability of these compounds to inhibit monoacylglycerol lipase and fatty acid amide hydrolase has been reinvestigated. The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic purposes.
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